The Role of Cavin3 in the Development of Malignant Tumors

Lei Qian,1,2,* Ziqian Zhang,3,* Hongning Cai2 1Hubei University of Medicine, Shiyan, Hubei Province, 442000, People’s Republic of China; 2Department of Hubei Clinical Medical Research Center for Gynecologic Malignancy, Maternal and Child Health Hospital of Hubei Province, Wuhan, People’s Republic of China; 3Department of Hubei Clinical Medical Research Center for Gynecologic Malignancy, Maternal and Child Health Hospital of Hubei Province, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongning Cai, Department of Hubei Clinical Medical Research Center for Gynecologic Malignancy, Maternal and Child Health Hospital of Hubei Province (Women and Children’s Hospital of Hubei Province), No. 745, Wuluo Road, Hongshan District, Wuhan, Hubei Province, 430070, People’s Republic of China, Email [email protected]: Cavin3, also known as PRKCDBP or SRBC, is an important member of the Cavin family. It plays a crucial role in the formation and functional regulation of caveolae while also acting as a tumor suppressor in the occurrence and development of most malignant tumors, primarily regulated by promoter region methylation. This paper systematically reviews the research progress of Cavin3 in breast cancer, lung cancer, gastric cancer, colorectal cancer and gynecological tumors, focusing on the role of Cavin3 in tumor prognosis and its possible regulatory mechanism. Current studies have shown that in breast cancer and lung cancer, Cavin3 can exert anti-tumor effects by inhibiting the PI3K/AKT signaling pathway and participating in DNA damage repair. In gastric cancer, it mainly activates downstream pathways by stabilizing p53, inducing cell cycle arrest and apoptosis. However, the specific role of Cavin3 in other tumor types and its broader regulatory mechanism have not yet been fully clarified and further in-depth research is needed. Future research on Cavin3 may provide new insights and effective strategies for precision diagnosis and treatment of malignant tumors.Keywords: Cavin3, tumor suppressor, biomarker, signaling pathway