Somatisation differentiates fibromyalgia from low back pain : a comparative, cross-sectional cohort study

Background and aims: To examine whether somatisation, depression, anxiety, fatigue, coping dimensions, pain, physical and social function, or sociodemographic characteristics can differentiate fibromyalgia from low back pain in a cross-sectional cohort setting of our Zurzach Interdisciplinary Pain Programme. Methods: Fibromyalgia and low back pain were compared using the Symptom Checklist-90R (SCL-90R) Somatisation scale, the Quantification Inventory for Somatoform Syndromes (QUISS) Number of somatoform symptoms, and other standardised instruments. Standardised mean differences (SMDs) quantified the score differences, and binomial logistic regression modelling with various co-variates differentiated fibromyalgia from low back pain. Results: The largest differences indicating worse health in fibromyalgia (n=131) were in somatisation on the SCL-90R (SMD=-0.971) and the QUISS (SMD=-0.960), next largest were the affective scores, and pain and coping (SMDs between -0.632 and -0.280, p≤0.007). Physical and social functioning were comparable in the two conditions (n=262 low back pain). The two somatisation scales both with odds ratios (OR)=0.966 (p≤0.002) plus female sex (OR=3.396, p<0.001) predicted 74.3% of the cases correctly (accuracy) with a positive predictive value of 65.3% and a specificity of 87.0% for fibromyalgia. In the female subsample (n=280), the model remained stable with an accuracy of 71.9%. Conclusions: Somatisation stood out from all other somatic, psychosocial, and coping dimensions and sociodemographics as the one significant specific predictor distinguishing fibromyalgia from low back pain. The fibromyalgia phenotype is characterised by the generalisation of painful loci but equally prominently by generalised somatoform symptoms. Assessment of somatisation is recommended to ensure accurate identification and understanding of the multifaceted syndrome of fibromyalgia.