Modelling the heat distribution in organ-on-a-chip systems using integrated microheaters

[Excerpt] Microfluidic systems with integrated heating transducers are of growing interest for applications in biochemical sensing, lab-on-a-chip and organ-on-a-chip (OoC) technologies [1]. Particularly, in OoC systems, temperature monitoring is crucial to maintain the cultured cells in a well-defined microenvironment for proper growth [2]. This monitoring can be achieved through temperature control systems combining microheaters and microsensors. Numerical simulation of these systems, based on multiphysics simulation tools, allow for an adequate prediction of the temperature distributions within the microfluidic module. [...]