Insulin Resistance Surrogates May Predict HTN-HUA in Young, Non-Obese Individuals

Yu-Qiang Zuo,1 Zhi-Hong Gao,1 Yu-Ling Yin,1 Xu Yang,1 Xing Guan,2 Ping-Yong Feng3 1Department of Physical Examination Center, The 2nd Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of China; 2Department of Physical Examination Center, The People’s Hospital of Shijiazhuang City, Shijiazhuang, Hebei, People’s Republic of China; 3Department of Imaging Center, The 2nd Hospital of Hebei Medical University, Shijiazhuang, Hebei, People’s Republic of ChinaCorrespondence: Ping-Yong Feng, Department of Imaging Center, The 2 nd Hospital of Hebei Medical University, and the Master Instructor of MM of the Imaging Medicine, Shijiazhuang, Hebei, People’s Republic of China, Email [email protected]: To compare the associations of three surrogate markers of insulin resistance (IR) [glucose and triglycerides (TyG index), TyG index with BMI (TyG-BMI), and the ratio of triglycerides divided by HDL-C (TG/HDL-C)] with hypertensive patients (HTN) plus hyperuricemia (HUA) (HTN-HUA) in young, non-obese individuals.Methods: Data from a cross-sectional epidemiological study of an annual health check-up population aged younger than 66 years were used to calculate the three IR surrogate indexes. The association with HTN-HUA and insulin resistance surrogates was examined with multinomial logistic regression and a receiver operating characteristic (ROC) curve.Results: A total of 6952 participants were included, including 671 (9.65%) participants with HTN alone, 272 (3.91%) participants with HUA alone, and 62 (0.90%) participants with HTN and HUA. Binary multiple-logistic regression results showed that TG/HDL-C was significantly correlated with HTN, HUA, and HTN-HUA. Compared with the lowest quartile, the odds ratios (95% CI) of the highest quartile of TG/HDL-C for HTN-HUA were 3.462 (1.138~10.530). TG/HDL-C and TyG-BMI had moderate discriminative abilities for HTN-HUA, and the area under the curve was 0.748 (0.682~0.815), 0.746 (0.694~0.798).Conclusion: Our study suggests that TG/HDL-C had a significant correlation with HTN-HUA and that TG/HDL-C had moderate discriminative abilities for HTN-HUA.Keywords: insulin resistance, TyG index, TG/HDL-C ratio, HTN-HUA