Influence of Placenta Extract Intake on Periodontal Diseases and Oral Environment: A Case Series

Hizuru Miyamoto,1 Kentarou Tahara,2 Eiichi Hirano2 1Dentistry and Oral Surgery of Happy Town, Shiki, Saitama, Japan; 2Medical Affairs Department, Japan Bio Products, Co., Ltd., Shibuya, Tokyo, JapanCorrespondence: Eiichi Hirano, Medical Affairs Department, Japan Bio Products, Co., Ltd., 1-30-22 Maplewood Bldg., 4F, Tomigaya, Shibuya, Tokyo, 151-0063, Japan, Tel +81-3-6804-8073, Fax +81-3-3481-6065, Email [email protected]: The placenta extract is used as a dietary supplement. We aimed to investigate the effects of placenta extract on periodontal disease.Case Presentation: In this study, placenta extract supplements were found to improve the oral environment of young and middle-aged Japanese women undergoing maintenance; after three months of taking placenta extract, bleeding upon probing was reduced. In addition, two parameters, white blood cells and protein, improved in the SillHa test, suggesting that the placenta extract contributes to the reduction of gingival inflammation through its anti-inflammatory effect. No adverse events were observed with the placenta extract.Conclusion: Placenta extract may lead to better management, including oral rehabilitation and pharmacotherapy. However, its effect on gingival inflammation requires further investigation in a larger number of cases.Keywords: bleeding on probing, SillHa, gingivitis, placenta extract, dentistry, periodontology