Dauricine: Review of Pharmacological Activity

Ke-Qian Chen,1,* Shu-Zhi Wang,2,* Hai-Bo Lei,1 Xiang Liu1 1Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China; 2Institute of Pharmacy and Pharmacology, School of Pharmaceutical Sciences, Hengyang Medical School, University of South China, Hengyang, 421001, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hai-Bo Lei; Xiang Liu, Department of Clinical Pharmacy, Xiangtan Central Hospital, Xiangtan, 411100, People’s Republic of China, Email [email protected]; [email protected]: Dauricine is an important natural organic compound in Menispermum dauricum, which often has significant biological activity.Purpose: The purpose of this review is to systemically summarize and discuss the pharmacological activity and underlying mechanisms of dauricine in recent years.Methods: Web of Science (121 articles) and PubMed databases (97 articles) were used to search for articles related to “dauricine” published from 2000 to 2024. Meanwhile, we classified the pharmacological activity of dauricine by screening these articles.Results: Emerging evidence suggests that dauricine possesses numerous pharmacological activities, including neuroprotection, anti-cancer, anti-arrhythmia, anti-inflammatory and anti-diabetes.Conclusion: Dauricine has a potential value in the treatment of many diseases. We hope that this review will contribute to therapeutic development and future studies of dauricine.Keywords: menispermum dauricum, dauricine, toxicity, pharmacology, pharmacokinetics