The Treatment and Evaluation of Dandruff and Scalp Erythema with Fermented Salix purpurea Bark Extract

Oliwia Kalinowska,1,&ast; Julia Ma&sacute;lana,1,&ast; Andrea Gilreath2 1J.S. Hamilton Poland Sp. Z o.o. Testing Laboratory, Gdynia, Poland; 2Actera Ingredients Inc, Newtown, PA, USA&ast;These authors contributed equally to this workCorrespondence: Andrea Gilreath, Actera Ingredients Inc, 66 Walker Ln, Newtown, PA, 18940, USA, Email [email protected]: The aim of this study was to gain knowledge of scalp and hair tolerance and efficacy of two investigational shampoo formulations with different concentrations of fermented Salix purpurea (purple willow) bark extract tested on dandruff sufferers.Methods: This non-invasive study included a trichologist assessment of tolerance, clinical evaluation of efficacy, and photo documentation by macrophotography with Aramo ASW 300F. Statistical analysis was conducted using paired sample t-tests or Wilcoxon signed-rank tests to assess within-group changes, and unpaired t-tests or Mann–Whitney U-tests to compare results between groups. A significance level of p < 0.05 was used to determine the efficacy of the treatments. A split-panel of 21 participants with varying scalp conditions, including visible dandruff, used the shampoos (Salixin Shampoo 2% or Salixin Shampoo 4%) for 56 consecutive days. Regular assessments were performed under trichological and dermatological supervision, including evaluation of scalp appearance, itching, redness, dandruff visibility, and subject-reported side effects.Results: Results indicated that both formulations were well tolerated. Evaluations demonstrated a reduction in dandruff symptoms for both shampoos, with Salixin Shampoo 4% showing a more pronounced effect, although not statistically significant.Conclusion: These findings suggest that fermented Salix purpurea bark extract is effective in reducing dandruff and improving scalp condition, with higher concentrations offering enhanced efficacy.Keywords: dandruff, scalp health, Salix purpurea bark extract, clinical evaluation, trichologist assessment, dermatological control