The Relationship Between Alzheimer’s Disease and Pyroptosis and the Intervention Progress of Traditional Chinese Medicine

Zixuan Zhang,1 Jing Bai,1 Siqi Zhang,1 Renzhen Wang,1 Shaobing Zhu,1 Tianyue Li,1 Miao Zhang2 1Graduate Schools, Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, People’s Republic of China; 2Acupuncture and Moxibustion 10 Departments, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, People’s Republic of ChinaCorrespondence: Miao Zhang, Acupuncture and Moxibustion 10 Departments, The Second Affiliated Hospital of Heilongjiang University of Traditional Chinese Medicine, Harbin, Heilongjiang, 150001, People’s Republic of China, Tel +86-13845088833, Fax +86-13114600132, Email [email protected]: Alzheimer’s disease (AD) is a progressive neurodegenerative disease caused by multiple causes. The main pathological features of AD are β-amyloid (Aβ) deposition, hyperphosphorylation of Tau protein, and progressive neuronal loss. Pyroptosis is one of the main forms of neuronal death, which is mainly caused by the activation of Gasdermin protein by upstream signals and the release of its N-terminal domain on the cell membrane. Studies have shown that there is a close relationship between Alzheimer’s disease (AD) and pyroptosis. Therefore, this paper summarizes the relationship between pyroptosis and its molecular mechanism and AD, as well as the related research of traditional Chinese medicine in the treatment of AD by regulating pyroptosis, in order to provide a new direction for the study of AD pathogenesis based on pyroptosis pathway.Keywords: Alzheimer’s disease, cell pyroptosis, inflammasome, traditional Chinese medicine