Recurrence of Rosacea Induced by Compound Vitamin Tablets: A Case Report

Hui-Shang Feng,1,2 Wan-Tong Zhang,3 Zi-Ye Xi,1 Guo-Dong Hua,4 Chun-Miao Xue,4 Ling-Ling Li,1 Shuang-Qing Qu,1 Li-Li Zhao,1 Tai Zhang,4 Bao-Chen Zhu,4 Yuan-Wen Li5 1Department of Dermatology, Dongzhimen Hospital Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 2Second Clinical Medical School, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 3Institute of Clinical Pharmacology, Xiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, People’s Republic of China; 4Department of Pharmacy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of China; 5Department of Dermatology, Dongfang Hospital, Beijing University of Chinese Medicine, Beijing, People’s Republic of ChinaCorrespondence: Bao-Chen Zhu, Department of Pharmacy, Dongzhimen Hospital, Beijing University of Chinese Medicine, Hai Yun Cang on the 5th Zip Dongcheng District, Beijing, 100700, People’s Republic of China, Email [email protected] Yuan-Wen Li, Department of Dermatology, Dongfang Hospital Beijing University of Chinese Medicine, No. 6 Fangxingyuan Fengtai District, Beijing, 100078, People’s Republic of China, Email [email protected]: We present a case of rosacea recurrence in a 37-year-old woman associated with the intake of compound vitamin tablets during the preconception period, with a Naranjo score of 7. These tablets, commonly used for nutritional supplementation to prevent anemia, contain a variety of vitamins, minerals, and trace elements. Despite their widespread use, reports of such supplements causing rosacea recurrence are rare. In this case, the patient experienced a recurrence of facial redness, stinging, and burning after taking the tablets on two separate occasions. Skin dermatoscopy, VISIA imaging, Clinician’s Erythema Assessment (CEA), Investigator’s Global Assessment (IGA), and Visual Analogue Scale (VAS) all confirmed the recurrence of rosacea. Given her intention to conceive, symptomatic treatment with emollient and reparative dressings was administered. The patient’s symptoms gradually resolved after discontinuing the medication, with no recurrence observed during follow-up visits. Women with a history of rosacea should avoid these tablets during preconception, pregnancy, and lactation to prevent recurrence and should choose supplements carefully to minimize the risk of rosacea flare-ups.Keywords: compound vitamin tablets, rosacea, drug adverse reaction, women of childbearing age, immune inflammatory dermatosis