Mediating Effects of Health Literacy, Self-Efficacy, and Social Support on the Relationship Between Disease Knowledge and Patient Participation Behavior Among Chronic Ill Patients: A Cross-Sectional Study Based on the Capability-Opportunity-Motivatio

Minjuan Wu,1 Wenqin Wang,1 Hongmei He,2 Liyun Bao,2 Peier Lv3 1School of Medicine, Quzhou College of Technology, Quzhou, People’s Republic of China; 2Department of Nursing, The First People’s Hospital of Lin’an District, Hangzhou, People’s Republic of China; 3Science and Education Department, The First People’s Hospital of Lin’an District, Hangzhou, People’s Republic of ChinaCorrespondence: Peier Lv, The First People’s Hospital of Lin’an District, No. 360 Yikang Street, Lin’an District, Hangzhou, 311301, People’s Republic of China, Tel +8615868415548, Email [email protected]: Patient participation is essential for improving patient safety and quality of care. It mainly refers to patients participating in their own healthcare through various ways, such as searching information on treatment options, engaging in decision-making, and communicating with healthcare professionals. This study aimed to investigate the relationships between disease knowledge, health literacy, self-efficacy, social support, and patient participation behavior in chronic ill patients based on the Capability-Opportunity-Motivation and Behavior (COM-B) model.Methods: This cross-sectional survey, conducted from October 2023 to January 2024, involved 389 chronic ill patients from five clinical departments (cardiology, endocrinology, respiratory medicine, neurology, and geriatrics) at a tertiary hospital in Hangzhou, Zhejiang Province. Patients completed the health literacy management scale, general self-efficacy scale, core knowledge of chronic diseases questionnaire, social support rating scale, and patient participation scale. We used t-tests / ANOVA, Pearson’s correlation coefficient, Fisher’s z-test, linear regression, and mediation model to analyze data.Results: The total effect of disease knowledge on patient participation behavior was significant (β = 0.496, p < 0.001), and the direct effect was also significant (β = 0.144, p < 0.001). Meanwhile, the relationship between disease knowledge and patient participation behavior was mediated by self-efficacy (β = 0.043, p < 0.001), health literacy (β = 0.027, p < 0.001), and social support (β = 0.193, p < 0.001), respectively.Conclusion: This study proposed a conceptual model that includes the mediating effects of health literacy, self-efficacy, and social support, which helps clarify the underlying mechanisms between disease knowledge and patient participation behavior. Targeted interventions to increase disease knowledge, health literacy, self-efficacy, and social support can help chronic ill patients engage more actively in their own healthcare.Keywords: self-efficacy, patient participation, health literacy, chronic diseases, social support