Kardiyovasküler Hastalığı Olmayan Obez Bireylerde Artmış Trombosit Sayısının Eritrosit Agregasyonu Üzerindeki Etkisi

Introduction: Although obesity raises the risk of cardiovascular illnesses, it is an important issue for public health. Platelets play important role in thrombosis and inflammation, and elevated number of platelets has been noted in obese individuals. Erythrocyte aggregation process involving the clumping of red blood cells, is influenced factors, including platelet activation. To investigate the relationship amongst platelet levels and erythrocyte aggregation in obese individuals. Methods: Anthropometric measurements of obese individuals (n=101) and non-obese controls (n=37) were recorded. Erythrocyte aggregation parameters, such as aggregation index (AI%), aggregation half-time (t1/2), and aggregation amplitude (AMP), were measured using a laser-based aggregometer. Platelet counts were determined by automated hematology analyzer. We concerned the anthropometric parameters, platelet counts, and erythrocyte aggregation measures. Results: Obese individuals had significantly higher BMI, fat percentage, fat mass, and fat-free mass versus non-obese controls. In the obese group, Fat mass, increasing fat percentage and BMI, were associated with decreased AMP and t1/2 values, and increased AI% values. Platelet counts were also significantly elevated in the obese group and were inversely correlated with AMP and t1/2 values. No significant associations were observed between anthropometric parameters, platelet counts, and erythrocyte aggregation measures in the non-obese group. Conclusion: There was strong association between elevated platelet levels and altered erythrocyte aggregation in obese individuals. Findings suggest that obesity-induced increases in platelet count may contribute to increased erythrocyte aggregation, potentially leading to an elevated risk of thrombotic events. Targeting platelet-related pathways may be a promising therapeutic strategy to mitigate cardiovascular complications in obese individuals.