Effect of Pergularia daemia Forsk. aqueous extract in Pentylenetetrazole-induced wistar albino rats Antiseizure study

Background: Epilepsy is a Neurological disease. It interferes with the brain's normal electrochemical functions. Similar to a seizure, Epilepsy is an indication of irregular brain activity. Aim: The current study aims to determine if the Aqueous leaf extract of Pergularia daemia Forsk. (AEPD) has the same anti-seizure activity of Pentylenetetrazole (PTZ) induced rats. Methods: Wistar albino rats were utilized in the studies, and the animals were randomly separated into groups. To determine the antiepileptic potential of rats given Pentylenetetrazole-induced epilepsy, doses of AEPD extract were administered at 100, 200, and 400 mg/Kg BW. Physical behaviors like immobility, swimming, and motor activities were assessed in the experimental animals. By analyzing the levels of neurotransmitters including GABA, Glutamate, Norepinephrine, serotonin, and Acetylcholinesterase in the animal's brain, the effect of PTZ was examined. Results: The results showed that on the 30th day, acute PTZ administration at a dose of (75 mg/kg bw) produced seizure, which increased immobility and reduced swimming time. Although the plant treatment in PTZ-induced groups showed glutamate, dopamine, serotonin, acetylcholinesterase, and GABA levels were all restored. The PTZ increased oxidative stress followed by neural and non-neural cells (Glial cells) degeneration, which altered levels of neurotransmitters. The results indicate that Pergularia daemia Forsk. a traditional source can be utilized to treat seizures.