Chemotherapy side effects in children and adolescents with leukemia and their relationship with maternal treatment Knowledge: A cross-sectional study

Background & Aim: Although chemotherapy is effective in treating leukemia, it is associated with multiple adverse effects. Mothers, as key members of the healthcare team, need adequate information regarding these side effects to provide optimal care. This study aimed to investigate the side effects of chemotherapy in pediatric and adolescent leukemia patients and examine their relationship with maternal treatment knowledge. Methods & Materials: This descriptive, cross-sectional study was conducted in 2023 and involved 110 mothers and their children aged 6-18 years hospitalized for leukemia at educational hospitals in Tabriz. A convenience sampling method was employed. Data collection instruments included the American Cancer Society's chemotherapy side effects checklist and an information questionnaire for parents of children with cancer, developed by Motlagh et al. The data were analyzed using SPSS version 24, applying chi-square tests, one-way ANOVA, paired t-tests, Pearson correlation coefficients, and repeated measures ANOVA. Results: The mean age of mothers was 37 years, and that of the children was 11.61 years. The majority of diagnoses were Acute Lymphoblastic Leukemia (ALL). The severity of complications—such as fever, nausea, vomiting, mouth mucositis, diarrhea, anorexia, and bleeding—showed a significant increasing trend over the four-week observation period (P<0.001). Additionally, a significant difference was observed in mothers' treatment knowledge between the first and fourth weeks (P<0.001). There was a significant relationship between chemotherapy complications and mothers' treatment knowledge (P<0.05). Conclusion: Mothers actively seek and obtain information regarding their children’s chemotherapy treatment, with their knowledge increasing as complication severity rises. Awareness of side effects and their management strategies enables parents to provide appropriate care and empowers caregivers to offer the best advice and support to patients and their families throughout the treatment course.