Clinicopathological Analysis of Patients with Isolated Hematuria and/or Mild Proteinuria

Junping Tang,1 Pingping Luo,2 Min He,1 Lin Ning,1 Zhenqin Tan2 1Nephrology Department of Yuebei People’s Hospital, Shaoguan, Guangdong, 512026, People’s Republic of China; 2Ophthalmology Department of Yuebei People’s Hospital, Shaoguan, Guangdong, 512026, People’s Republic of ChinaCorrespondence: Pingping Luo, Ophthalmology Department of Yuebei People’s Hospital, No. 133, Huimin South Road, Shaoguan, Guangdong, 512026, People’s Republic of China, Tel +86 15992962195, Email [email protected]: This investigation aimed to explore the clinicopathological features of patients with isolated hematuria and/or mild proteinuria in kidney disease.Materials and Methods: We conducted a retrospective review of the clinical and pathological information of patients initially diagnosed with chronic nephritis syndrome in the Nephrology Department of Yuebei People’s Hospital.Results: In total, 227 participants were recruited for the study, including 79 patients (34.8%) in the group with isolated hematuria and/or mild proteinuria and 148 patients (65.2%) in the group with medium-large amounts of proteinuria. There were 29 cases (36.7%) of IgA nephropathy, seven cases (8.9%) of focal segmental glomerulosclerosis, six cases (7.6%) of membranous nephropathy, and six cases (7.9%) of acute renal tubular injury in the group with isolated hematuria and/or mild proteinuria. The common pathological types in the medium-large proteinuria group were membranous nephropathy in 68 cases (45.9%), minimal change nephropathy in 25 cases (16.9%), and IgA nephropathy in 20 cases (13.5%).Conclusion: IgA nephropathy is the main pathological type in the group with isolated hematuria and/or mild proteinuria, while membranous nephropathy is the common pathological type in the group with moderate to severe proteinuria. There was a significantly stronger correlation between the level of hematuria/proteinuria and both BMI and MAP.Keywords: isolated hematuria, proteinuria, renal biopsy puncture