Celiac Disease and Incident Dupuytren’s Contracture: A Matched Nationwide Cohort Analysis

Shuai Yuan,1 Dominic Furniss,2 Susanna C Larsson,1,3 Daniel A Leffler,4 Jonas F Ludvigsson5– 7 1Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden; 2Nuffield Department of Orthopaedics, Rheumatology, and Musculoskeletal Sciences, University of Oxford, Oxford, UK; 3Department of Surgical Sciences, Uppsala University, Uppsala, Sweden; 4The Celiac Center at Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA; 5Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden; 6Department of Pediatrics, Orebro University Hospital, Orebro, Sweden; 7Department of Medicine, Celiac Disease Center at Columbia University Medical Center, New York, NY, USACorrespondence: Shuai Yuan, Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden, Email [email protected]: This study explored the association between celiac disease (CeD) and Dupuytren’s contracture (DC) using data from the Swedish ESPRESSO cohort. We analyzed 49,699 CeD patients and 245,267 matched controls, identifying 1420 incident DC cases. CeD patients had a 1.21-fold increased risk of DC compared to controls, with a more pronounced risk in women and older individuals. Further research is needed to understand the underlying mechanisms of this relationship.Plain Language Summary: Dupuytren’s contracture is characterized by hard nodules in the palm, leading to finger flexion and impairing activities like writing and cooking. The disease has been linked to a higher prevalence among individuals with immune-mediated diseases but there are little data on the association with celiac disease. In this study we used register-based data to follow-up some 49,000 individuals with celiac disease and 245,000 individuals from the general population. A higher proportion of individuals with celiac disease developed Dupuytren’s contracture, corresponding to a 21% increased risk.Keywords: celiac disease, Dupuytren’s contracture, immune-mediated disorders, cohort analysis