Antihypertensive Capabilities of Gallic Acid–Derived Esters

Hypertension is the most predominant risk factor for the onset of cardiovascular disease in the world and is one of the largest causes of mortality worldwide. Current treatments for the condition vary significantly due to individual circumstances, with severe cases often involving the usage of careful dosages of custom combinations of medicines to minimize unintended effects. Thus, great priority is given to discovering novel economical antihypertensive treatments with minimal adverse effects. Morus Alba, a tree cultivated for thousands of years in Asia, has recently gained traction as a potential source of medicinal compounds due to its usage in traditional medicines and rich polyphenol content. One major bioactive substance present in Morus Alba is 3,4,5- trihydroxybenzoic acid or gallic acid, which has demonstrated potential antihypertensive capabilities, such as in the inhibition of the renin-angiotensin system. This research aims to investigate the antihypertensive capabilities of gallic-acid based molecules through computational docking with the protein structure of the angiotensin-converting enzyme in the program SeeSAR, which has generated several potential angiotensin-inhibiting esters. Another set of laboratory procedures created and explored several pathways to synthesize and purify the discovered medicines. Results are to be presented.