Predictive Value of Current Perception Threshold for Prognosis of Pulsed Radiofrequency in Patients with Acute Herpetic Neuralgia

Chengcheng Zhao,1,2 Ziwei Lu,1,2 Bohan Hua,1,2 Jiayu Yue,2 Qinru Yang,2 Huadong Ni,2 Ming Yao2 1Jiaxing University Master’s Degree Cultivation Base, Zhejiang Chinese Medical University, Jiaxing City, Zhejiang Province, People’s Republic of China; 2Department of Anesthesiology and Pain Research Center, The Affiliated Hospital of Jiaxing University, Jiaxing City, Zhejiang Province, People’s Republic of ChinaCorrespondence: Ming Yao, Email [email protected]: This study aimed to evaluate the prognostic accuracy of the Current Perception Threshold (CPT) in Acute Herpetic Neuralgia (AHN) patients receiving Pulsed Radiofrequency (PRF) therapy and to develop a corresponding prognostic model.Methods: We retrospectively analyzed data from 106 AHN patients treated with PRF between January 2022 and May 2023. The occurrence of Postherpetic Neuralgia (PHN) after treatment categorized patients into non-PHN and PHN groups. The predictive role of CPT indices for PRF outcomes was assessed using the Receiver Operating Characteristic (ROC) curve and Area Under Curve (AUC). Then the dataset was split into a training set (n=74) and a validation set (n=32). Factors associated with PHN development were identified using univariate and multivariate logistic regression. A nomogram model was developed using significant predictors and internal validation was performed using valid set data.Results: Among the 106 patients, 45 had a poor prognosis. Significant differences in age, preoperative Numerical Rating Scale (NRS) score, and 5Hz CPT ratio were observed between the groups (p< 0.05). Logistic regression identified these factors as independent predictors for PRF prognosis (p< 0.05). The 5Hz CPT ratio demonstrated predictive value (AUC= 0.764, 95% CI: 0.674– 0.855). The nomogram model, incorporating these predictors, showed high AUC in both the training (0.863, 95% CI: 0.776– 0.950) and validation sets (0.859, 95% CI: 0.721– 0.998). Calibration curves indicated good model fit, and the Hosmer-Lemeshow test confirmed this (p> 0.05). Decision Curve Analysis (DCA) highlighted the model’s predictive advantage.Conclusion: The 5Hz CPT ratio can predict the prognosis of PRF in AHN patients. The nomogram model has high precision and clinical utility. It can help identify AHN patients with a poor PRF prognosis at an early stage and assist in clinical decision-making.Keywords: current perception threshold, neuralgia, postherpetic, pulsed radiofrequency treatment, predictive model