The phenotypic presentation and optokinetic response of DCBLD1 in zebrafish

The orphan receptor DCBLD1 (Discoidin, Cub, and LCCL domain-containing receptor 1) is found in the plasma membrane of multiple tissue types in vertebrates. DCBLD1 is upregulated in tissues following vascular repair and tumor migration, but its specific function in nervous system development has not yet been determined. This study will delve into the effects on zebrafish development when DCBLD1 is absent by analyzing the retina's cellular integrity and optokinetic function compared to wildtype fish. Through this, knowledge of the necessity of DCBLD1 will be furthered and its impacts will be compared to its sister gene DCBLD2.

Publication Details

Journal
ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Published
2025-06-02
Primary Topic
Cell Adhesion Molecules Research
Type
article
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article

The phenotypic presentation and optokinetic response of DCBLD1 in zebrafish

ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
Cell Adhesion Molecules Research
article

The phenotypic presentation and optokinetic response of DCBLD1 in zebrafish

article en

Abstract

The orphan receptor DCBLD1 (Discoidin, Cub, and LCCL domain-containing receptor 1) is found in the plasma membrane of multiple tissue types in vertebrates. DCBLD1 is upregulated in tissues following vascular repair and tumor migration, but its specific function in nervous system development has not yet been determined. This study will delve into the effects on zebrafish development when DCBLD1 is absent by analyzing the retina's cellular integrity and optokinetic function compared to wildtype fish. Through this, knowledge of the necessity of DCBLD1 will be furthered and its impacts will be compared to its sister gene DCBLD2.

ScholarWorks -A service of University of Vermont Libraries (University of Vermont)
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Cell Adhesion Molecules Research
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The phenotypic presentation and optokinetic response of DCBLD1 in zebrafish · ScholarWorks -A service of University of Vermont Libraries (University of Vermont) (2025) | TGRS Research Map | TGRS