LYELL'S SYNDROME IN THE PRACTICE OF AN ONCOLOGIST (CLINICAL CASE)

The article describes a rare clinical case of Lyell's syndrome in a patient with a malignant neoplasm of the sigmoid colon with bilobar metastases to the liver, a history of palliative resection of the sigmoid colon, who was prescribed therapy with the BRAF inhibitor Vemurafenib. While taking the drug, toxic epidermal necrolysis, a generalized form, developed. Toxic epidermal necrolysis (TEN, Lyell's syndrome) is an acute, life-threatening mucocutaneous reaction characterized by skin tenderness, erythema, extensive necrosis and epidermal detachment. The incidence rate is from 0.4 to 1.2 cases per million person-years and mortality up to 50 %. Representatives of the female sex are more often affected. The incidence increases with age and is higher after the fourth decade of life.