Mathematical modeling of the targeted atomization of medicinal drugs into anatomical airways

The targeted drug delivery into the airways is of great interest. In the practice of respiratory medicine the advances in this direction favor immediately the medical treatment efficiency, the prevention of the aggravation of chronical respiratory pathologies, and the preventive measures against the chronicity of the processes in the lungs and airways. The efficient targeted delivery is impossible without a detailed analysis of the physical features of the aerosol spraying of medicinal drugs into the airways. At present, this direction actively develops and evolves using the present-day methods of analysis. In particular, the results of the studies have led to the fundamental progress in the domain of fine aerosols, namely, an increase in the respirable fraction and the lung deposition of aerosol medicinal drugs at the expense of an increase in the<br/>faction of the inhaled particles or drops in the range from 1 to 5 μm. We have reviewed the mathematical models of the targeted drug atomization in the airways. The key formulated problems in the domain of how the results of the fundamental experiments and the modeling with account for the thermophysical and hydrodynamic features and the molecular structure can be helpful in the accurate prediction and negotiation of complicated individual systems of lung barriers.