Evidence Summary of Early Enteral Nutrition Support for Adult Patients with Extracorporeal Membrane Oxygenation (ECMO)

Jixiang Guo,1,2 Zhiyi Wang,2 Aiqun Liang,1 Zhi Qu,2 Hanru Bao,1,2 Kexi Pei,3 Xiaoping Luo1 1Surgery and Anesthesiology Department 1, Zhongshan People’s Hospital, Zhongshan, Guangdong, 528403, People’s Republic of China; 2School of Nursing and Health, Henan University, Kaifeng, Henan, 475004, People’s Republic of China; 3Medical Intensive Care Unit, Zhongshan People’s Hospital, Zhongshan, Guangdong, 528403, People’s Republic of ChinaCorrespondence: Xiaoping Luo, Surgery and Anesthesiology Department 1, Zhongshan People’s Hospital, 2 Sun Wen East Road, Zhongshan, Guangdong, People’s Republic of China, Email [email protected]: This study aims to systematically review and summarize the evidence on early enteral nutrition (EEN)support for Extracorporeal Membrane Oxygenation (ECMO)patients, Offer evidence-based guidance to healthcare professionals, including doctors and nurses, to inform their clinical practices.Methods: Using the “ 6S”evidence-based model, we searched multiple databases including UpToDate, Best Practice, Guideline International Network (GIN), National Guideline Clearinghouse (NGC),Registered Nurses’ Association of Ontario (RNAO), Joanna Briggs Institute (JBI), Evidence-Based Healthcare Center database, the Cochrane Library, PubMed, Embase, Web of Science, China National Knowledge Infrastructure (CNKI),Wanfang Database, and Chinese Biomedical Literature Database (CBM). Aiming to find evidence on early enteral nutrition support for adult patients with extracorporeal membrane oxygenation. The search included clinical decisions, guidelines, systematic reviews, evidence summaries, and expert consensus. The time frame for the search was from the inception of the databases to September 10, 2024.Two researchers evaluated the quality of the collected literature and extracted data and summarized evidence from publications that met the quality criteria.Results: We retrieved 13 relevant documents, consisting of 6 guidelines, 3 expert consensus papers, 2 clinical decision-making articles, and 2 cohort studies. Through summarization and induction, a total of 26 best evidence pieces were obtained across five aspects: the establishment of nutritional support plans; strategies and risk assessment for enteral nutrition; the implementation of early enteral nutrition supplementation strategies; the amount and composition of nutrients reaching standard intake; and prevention of enteral nutrition-related complications.Conclusion: This study has summarized the evidence regarding early enteral nutrition support for adult patients with extracorporeal membrane oxygenation (ECMO). It provides an evidence-based foundation for the practice of nursing and assists medical staff in developing personalized nutrition management plans for enteral nutrition support in ECMO patients.Keywords: extracorporeal membrane oxygenation, ECMO, early enteral nutrition, nutrition support, evidence summary