The Association Between D-Dimer Levels and Recurrence in Patients with Early-Stage Cervical Cancer after Surgical Treatment

Qin Chen,1,* Lele Zang,1,* Qin Xu,1 Min Wang,1 Huaqin Lin,1 Yanyan Liu,2 Yi Fang1 1Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, Fujian Province, 350014, People’s Republic of China; 2Department of Oncology, Wuping County Hospital, Longyan, Fujian Province, 364300, People’s Republic of China*These authors contributed equally to this workCorrespondence: Qin Chen; Yi Fang, Department of Gynecology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, 420# Fuma Road, Fuzhou, Fujian Province, 350014, People’s Republic of China, Tel +86-15359734658, Email [email protected]; [email protected]: This study was conducted to analyze the relationship between plasma D-dimer levels and the risk of recurrence after surgical treatment in patients with early-stage cervical cancer (CC).Methods: In this cohort study, 888 participants with early-stage CC undergoing surgical treatment in Fujian Cancer Hospital between June 2016 and December 2019 were identified. Univariate logistic regression was used to screen confounding factors affecting the recurrence of early CC after surgical treatment. Variables significantly associated with the recurrence of early CC after surgical treatment were confounding factors. Univariate and multivariate logistic regression models were established to explore the association between D-dimer levels and the risk of recurrence of early CC after surgical treatment. ORs and 95% CIs were calculated.Results: The end of follow-up was when CC recurred or 3 years after surgery. In sum, 80 patients suffered CC recurrence, accounting for 9% of all participants. The risk of recurrence was elevated in CC patients from the elevated group (EG), with an adjusted OR of 2.16 (95% CI 1.28– 3.62). The risk of recurrence was increased in the EG in patients with cervical squamous cell carcinoma undergoing surgery in the adjusted model (OR 3.58, 95% CI 1.02– 12.89). As for cervical adenocarcinoma patients, the increased risk of recurrence was identified in patients from the EG (OR 1.87, 95% CI 1.01– 3.48).Conclusion: High levels of D-dimer were associated with increased recurrence risk of CC in patients at the early stage of surgical treatment.Keywords: D-dimer, cervical cancer, surgical treatment, recurrence