Association Between Serum Uric Acid to Creatinine Ratio and Metabolic-Associated Fatty Liver Disease in Southeast China (TyG-BMI as a Potential Mediator)

Bingbing Chen,1 Xian-E Peng2 1Department of Hospital Infection Control, First Hospital of Quanzhou Affiliated to Fujian Medical University, Quanzhou, People’s Republic of China; 2Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, People’s Republic of ChinaCorrespondence: Xian-E Peng, Department of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, Fujian, 350122, People’s Republic of China, Tel +86-13809516580, Fax +86-591-22862648, Email [email protected]: Serum uric acid to creatinine ratio (SUA/Cr) has been associated with an increased risk of metabolic syndrome; however, limited evidence exists regarding the relationship between SUA/Cr and metabolic-associated fatty liver disease (MAFLD). This study aims to investigate the association between SUA/Cr, TyG-BMI (triglyceride glucose-body mass index), and MAFLD in Chinese adults.Patients and Methods: The data were obtained from a health examination conducted at Nanping First Hospital. Spearman correlation analysis was employed to assess the association between SUA/Cr or TyG-BMI and various risk factors pertinent to MAFLD. A multivariate logistic regression model was utilized to investigate the relationship between SUA/Cr or TyG-BMI and MAFLD. Additionally, restricted cubic splines (RCS) and receiver operating characteristic (ROC) curve analyses were applied to explore the relationship between SUA/Cr and MAFLD. Mediation models were constructed to figure out the mediating role of TyG-BMI in the association between SUA/Cr and MAFLD.Results: Spearman correlation analysis showed a significant association between SUA/Cr and multiple risk factors for MAFLD (such as BMI, SBP, DBP, TG, TC, ALT, AST, GGT, FPG, and HDL). Furthermore, SUA/Cr had a positive correlation with TyG-BMI (P< 0.05). The logistic model demonstrated that elevated levels of SUA/Cr were significantly associated with an increased risk of MAFLD, even after adjusting for confounding factors (odds ratio [OR]: 1.390; 95% confidence interval [CI]: 1.255– 1.538). The RCS curves revealed a consistent and monotonic increase in the relationship between SUA/Cr levels and the occurrence of MAFLD. Moreover, SUA/Cr exhibited moderate discriminatory ability in identifying individuals with MAFLD (AUC: 0.669). Mediation analysis indicated that approximately 52.05% of the positive association between SUA/Cr and MAFLD was mediated by TyG-BMI.Conclusion: Our findings suggest a substantial association between elevated levels of SUA/Cr and an increased risk of MAFLD in the Chinese adult population, with TyG-BMI mediating this correlation.Keywords: SUA/Cr, TyG-BMI, metabolic-associated fatty liver disease