Розроблення складу та технології виготовлення суспензії з адапаленом для лікування акне з урахуванням біофармацевтичних чинників

The aim of the research is the development of the suspension with adapalene for use in the symptomatic block of complex acne therapy composition and technology of preparation. Materials and methods. The objects of the study were suspension samples, which included active pharmaceutical ingredients (adapalene, hyaluronic acid, liquid aloe extract and zinc oxide), and purified water. Results. Hyaluronic acid was determined as the optimal stabilizer and its concentration was selected using the resuspension method, at which the suspension is a stable system. It was established that the samples, which include adapalene, zinc oxide, liquid aloe extract, hyaluronic acid and purified water, have satisfactory physical and chemical properties. Conducted rheological studies showed that due to the potentiation of associative thickening, optimal rheological indicators of the suspension, which affect both the extrusion and consumption properties of the developed suspension, were obtained. The quantitative content of adapalene in the developed suspension was confirmed by the method of alkalimetry. The completeness and speed of release of adapalene from the suspension was confirmed by the method of dialysis through a semipermeable membrane. Conclusions. An extemporaneous suspension, based on adapalene, zinc oxide and liquid aloe extract, with the addition of a stabilizer – hyaluronic acid, was developed. The proposed suspension has satisfying consumer, physical and chemical properties, and meets the quality requirements established for suspensions