Narrow-field input naar het intermediaire Superior Colliculus faciliteert voorpoot reikwijdte bewegingen via projecties naar de Pontine Reticular Nucleus

To generate an appropriate motor performance in the complex natural environment, the nervous system must simultaneously process and integrate multiple streams of sensory information. While role of proprioceptive feedback and its connectivity to motor output circuits has been studied extensively, circuit-level knowledge linking visual feedback to motor function is largely limited to arousal, orienting and innate behavioral functions. Preliminary results from my Ph.D. thesis laboratory suggest that while visual input is critical for successful learning and execution during a forelimb reaching/grasping assay, primary visual cortex (i.e., visual awareness) is not. Using a multi-disciplinary approach of high-speed three-dimensional movement kinematics, mouse genetics, virus-mediated circuit tracing, optically-identified neuronal recordings and optogenetic or pharmacogenetic manipulations, I aim to study 1) which visual feedback circuit components in a cell-type specific manner are required for motor learning and appropriate motor execution, and 2) whether and how visual and proprioceptive feedback integrate distinct individual sensory modalities to accommodate successful forelimb reaching movement. Successful implementation of the study will lead to valuable information to design neural prostheses and inspire new therapeutic approaches to facilitate not only motor learning but also recovery of motor functions.