Multipl Sklerozda Aktif ve İnaktif Demiyelinizan Plakların Değerlendirilmesinde Dinamik Duyarlılık Kontrastlı Perfüzyon Manyetik Rezonans Görüntülemenin Rolü

BackgroundOur goal in this study was to find out if active plaques that exhibit enhancement and inactive plaques that do not differ in DSC-PWI measures in MS patients.Material and Methods:In our study, Dynamic susceptibility contrast perfusion-weighted MRI (DSC-PI) examinations of 30 patients diagnosed with Multiple Sclerosis were retrospectively analyzed. A region of interest (ROI) was manually drawn on DSC-PI between active plaques that showed enhancement on conventional MRI sequences and inactive plaques that did not show enhancement. Cerebral blood volume (CBV), cerebral blood flow (CBF), mean transit time (MTT) and time to peak (TTP) in this ROI were also recorded. These measurements were also normalized to apparently unaffected contralateral white matter hemisphere measurements. These normalized values were named rCBV, rCBF, rMTT and rTTP.Results:Both rCBV and rCBF were significantly higher in active demyelinating plaques compared to chronic demyelinating plaques (p