Inhibition of adipocyte lipolysis in lung cancer cachexia

Cancer cachexia (CC) is a wasting syndrome that occurs during lung cancer and is characterized by the loss of skeletal muscle and adipose tissue. Adipose tissues store fats as triglycerides until they are needed by the body for energy during fasting. When these triglycerides are released, it is called lipolysis. Lipolysis is characterized by a decrease in adipocyte size, which can be quantified from adipose tissue sections using imaging-based techniques. My aim was to determine whether the pharmacological inhibition of lipolysis prevents decreased adipocyte size in mice with CC using data from the quantification and analysis of adipose tissue sections.