An Unusual Case of Myelomatous Pleural Effusion in Nonsecretory Myeloma

Non-secretory MM account for 3% to 5% of the total MM population and total incidence of pleural effusion (PE) in MM is only 6%. In this case, patient developed PE during the disease course emphasizing the rarity of PE in NSMM. Mostly PE is attributed to infective causes, but the presence of myeloma cells in a PE along with the involvement of bone marrow is a very rare scenario that emphasizes the importance of detailed evaluation of such patients by both clinicians and pathologists.