Symptomatic Nursing Management of Advanced Breast Cancer with Multiple Metastases During DS-8201 Treatment: A Case Report and Literature Review

Na Liu,1,* Chunhua Zhao,2 Dan Li,1,* Siqi Liu,1 Hongyan Sun2 1Department of Breast, Electric Power Hospital, Beijing, 100073, People’s Republic of China; 2Nursing Department, Electric Power Hospital, Beijing, 100073, People’s Republic of China*These authors contributed equally to this workCorrespondence: Chunhua Zhao, Nursing Department, Electric Power Hospital, No. 1 Xilijia, Taipingqiao, Fengtai District, Beijing, 100073, People’s Republic of China, Tel +86-010-63501188, Email [email protected]: To summarise the therapeutic effects of symptomatic nursing during DS-8201 (Enhertu) treatment in a patient with advanced breast cancer with metastases to the ribs, lungs and liver. The patient, diagnosed with breast cancer with multiple metastases, was admitted to the hospital on 4 January 2021, 2 months after the discovery of a right breast mass. DS-8201 was administered during this period, and nursing care was tailored to address the patient’s symptoms while on the medication. Before treatment, the Hamilton Anxiety Scale score was 22, the Pittsburgh Sleep Quality Index score was 19 and the Insomnia Severity Index score was 24. After treatment, the SAS score decreased to 15, the PSQI score to 12 and the ISI score to 11, indicating improvements in sleep quality and anxiety. Re-examination showed minimal change in left breast nodules compared with previous results, with no additional metastases detected. By the follow-up in September 2023, the patient showed no signs of obvious recurrence and had not returned to the hospital for further consultation. During a telephone follow-up in October 2023, the patient reported no significant discomfort, her condition remained stable and her health indicators were well controlled while on the medication. This study details the symptoms and corresponding nursing interventions for patients with advanced breast cancer undergoing DS-8201 treatment, providing a nursing reference for future patient care.Keywords: breast cancer, multiple metastases, Enhertu, nursing