Risk of Relapse Following Discharge from Non-Hospital Residential Opioid Use Disorder Treatment: A Systematic Review of Studies Published from 2018 to 2022

Orrin D Ware,1 Gabriella Rose Geiger,1 Veronica D Rivas,2 Miracle A Macias Burgos,3 Lea Nehme-Kotocavage,4 Tara G Bautista2 1School of Social Work, University of North Carolina at Chapel Hill, Chapel Hill, NC, USA; 2Department of Psychological Sciences, Northern Arizona University, Flagstaff, AZ, USA; 3Clinical Translational Sciences, University of Arizona, Tucson, AZ, USA; 4Department of Psychology, Florida International University, Miami, FL, USACorrespondence: Orrin D Ware, University of North Carolina at Chapel Hill, School of Social Work, 325 Pittsboro Street, Chapel Hill, NC, 27599, USA, Email [email protected]: Relapsing on opioids after residential treatment may involve fatal outcomes, considering the potential for reduced tolerance and the potency of fentanyl in the illicit opioid market. The present paper examines recent literature on the risk of relapse among adults with opioid use disorder after discharge from residential treatment. We searched for published studies from 2018 to 2022 through database searches, including CINAHL, PsychINFO, PubMed, and Scopus. Across the N=10 studies included in this review, returning to substance use after residential treatment was captured differently, including self-report, hair samples, and urine samples. Follow-up relapse data after discharging from treatment was also captured across different time periods of included studies ranging from one month to six months. Variability was also identified in the percentage of individuals who relapsed after treatment, ranging from 0% to 95%. Considering the potential for a fatal overdose in the current fentanyl era, it is imperative to provide resources during residential treatment that can reduce the risk of relapse after discharge.Keywords: adult, non-hospital residential, recovery, returning to patterns of use, review