Scalable Biocatalytic Oxygenation of Aliphatic Amine Derivatives Using a Class I Unspecific Peroxygenase

artUPO is revealed as an effective biocatalyst for the regioselective oxygenation of cycloalkylamines to form cyclic amino ketones on preparative scale. Furthermore, amino alcohols can be formed via the selective C-H oxygenation of isopropyl-tethered amine derivatives. Enantiomerically enriched amino alcohols are also accessible using a kinetic resolution approach.