Los extractos de Albizia julibrissin y Caesalpinia decapetala inducen la inhibición potencial de enzimas y el crecimiento celular a través de la actividad antiacetilcolinesterasa, antilipasa, antiglicación y citotoxicidad

Introduction: Medicinal plants are dynamic source of human health because of their therapeutic potential in treating various ailments. This study aimed to determine the anti-acetylcholinesterase, anti-lipase, anti-glycation and anti-cancer activities of Albizia julibrissin and Caesalpinia decapetala (family Fabaceae). Methods: The leaf extracts were prepared to investigate their inhibitory capacities against acetylcholinesterase, lipase and glycation products. The anti-cancer potential was evaluated against HeLa, PC3 and 3T3 cell lines using MTT assay and HPLC analysis was done to quantify six compounds. Results: Results indicated highest anti-acetylcholinesterase (IC50 2.391 µg/ml) activity in A. julibrissin methanolic extract while highest anti-lipase (114.9 µg/ml) and anti-glycation (43.69 µg/ml) activity was recorded in C. decapetala methanolic extract. Highest cytotoxic potential was also observed in C. decapetala against PC3, 3T3 and HeLa cell lines (144.3 ppm, 201.0 ppm and 236.0 ppm). In the end, HPLC showed that A. julibrissin exhibit the highest concentration of chlorogenic acid (56.06 ppm) and quercetin dihydrate (15.71 ppm) while C. decapetala leaves extracts possess highest concentration of gallic acid (73.55 ppm). Conclusions: The results suggest that these extracts significantly inhibit the enzymatic activities, glycation products and the growth of cytotoxic cells and thus, can be used as novel pharmacological leads to treat various diseases.