MACRO AND MICROSCOPIC CHANGES IN THE SPINAL CORD TISSUE IN NORMAL AND UNDER CONDITIONS OF THE METABOLIC SYNDROME

In our study of morphological changes in the spinal cord in metabolic syndrome, we observed different changes in young and old individuals. At the histological level, we observed the reaction of blood vessels, but the manifestations of these reactions were different in old and young animals. In young rats, sinusoids in the form of long cavities were observed in the white matter, and in the gray matter there were vessels of different diameters, some of them were dilated with stasis and located among multidirectional nerve fibers, and they contained single fillings with shaped elements. Changes in the vascular component were also observed in old rats, but all manifestations were less pronounced. The vessels were of different diameters, and the phenomena of stasis and its consequences were almost not observed, but these vessels were located more fragmentarily and visually there were more of them, more often, they were completely filled with shaped elements and were also located around different directions of fibers, among which there were corkscrew- shaped fibers, edema was less and sinusoids were reduced in diameter. Thus, in young forms, there was a more aggressive reaction of blood vessels, both in the tissue of white matter and gray matter of the spinal cord, because young individuals are more active and the reaction of blood vessels, as a response to the increased pressure that occurs in the conditions of the metabolic syndrome, is more provocative. Changes in the vascular component were also observed in old rats, but despite the manifestations, this reaction is slower, as they almost do not move, especially considering the signs of the consequences of the metabolic syndrome, therefore, although the microscopic picture was also pronounced, stagnation prevailed.