The Effects of Different Ciprofol Doses on Hemodynamics During Anesthesia Induction in Patients Undergoing Cardiac Surgery: A Randomized, Double-Blind, Controlled Study

Yingting Zhou,1 ZiYou Liu,1 QianQian Li,1 PengFei Ni,1 ZuoHui Li,2 BeiJia Yu,2 Min Zhang,1 Jia Yang,1 YanHu Xie1 1Department of Anesthesiology, The First Affiliated Hospital of USTC, Division of Life Sciences and Medicine, University of Science and Technology of China, Hefei, Anhui, 230001, People’s Republic of China; 2First Clinical Medical College, Gannan Medical University, Ganzhou, Jiangxi, 341000, People’s Republic of ChinaCorrespondence: YanHu Xie, Email [email protected]: To evaluate the effects of different ciprofol doses on hemodynamics in patients undergoing cardiac surgery.Methods: 209 patients were randomly divided into four groups: 0.2 mg/kg etomidate group (group E, n = 50), 0.2 mg/kg, 0.3mg/kg, 0.4mg/kg ciprofol group (group A, n = 53, group B, n = 51, group C, n = 54). Mean arterial pressure (MAP), heart rate (HR), cardiac output (CO), stroke volume (SV), systemic vascular resistance (SVR), and bispectral index were recorded at the following time points: 5 minutes after entering the operating room (T0); before anesthesia induction (T1); immediately after induction (T2); 1 minute and 2 minutes after induction (T3~T4); at intubation (T5); 1 minute, 3 minutes, 5 minutes and 10 minutes after intubation (T6~T9); at skin incision (T10). The incidence of hypotension and bradycardia and the doses of vasoactive drugs were recorded.Results: Compared with T0, HR, MAP, SV, CO all decreased to varying degrees after administration, and the decrease time in Group B and Group C were earlier than that in other two groups (P < 0.05). SVR increased slowly after T4 in all groups, but there was no significant differences (P > 0.05). Compared with group E, the norepinephrine dose was significantly lower in groups A and B (both P < 0.05). Group C showed a greater decline in CO and SV than the other three groups from T7 to T10 (P < 0.05), while there was no significant difference between groups A and E in CO and groups A, B, and E in SV (P > 0.05). No significant differences were observed in MAP, SVR, and the incidences of hypotension and bradycardia among the four groups (P > 0.05).Conclusion: 0.2 mg/kg ciprofol has the least impact on hemodynamics in patients undergoing cardiac surgery, and reduced norepinephrine use.Keywords: ciprofol, hemodynamics, cardiac surgery