Clinical and biochemical compare of perimenopausal and menopausal women

Background: Menopause is an integral part of female normal physiology as outcomes of most vital non-modifiable risk factor of aging with symptoms ranging from trivial to ominous. Objectives: To compare levels of Serum free T4 (fT4), Thyroxine (T4), Thyroid-Stimulating Hormone (TSH), Total Cholesterol, low-density lipoprotein-cholesterol (LDL-C), High-density lipoprotein cholesterol (HDL-C), Triglyceride, Total calcium, Total phosphorus, Serum alkaline phosphatase (ALP) and Vitamin D3. Methods: An open label analytical cross-sectional non-interventional study was conducted on 120 consecutive female patients in their perimenopausal and menopausal phases of life at the departments of Biochemistry and Obstetrics & Gynecology of the tertiary care teaching institute of eastern India from October 2023 to March 2024. Results: Thyroid, Calcium and Lipid profiles of 60 perimenopausal women were compared with that of 60 menopausal women. fT4, T4 and TSH levels were lower among menopausal group though not statistically significant. In menopausal group, mean Calcium levels were higher and phosphors levels lower than perimenopausal group without significant difference. Mean ALP levels in menopausal group were higher, while Mean Vitamin D3 levels lower; both disparities were highly significant. Mean Cholesterol and Triglyceride levels were significantly higher in menopausal group. Mean LDL-C levels were higher and Mean HDL-C was lower in menopausal women; these differences insignificant. Conclusion: Our study suggests a necessity to assess functional status and metabolic transition in Thyroid, Calcium and Lipid profile periodically in the perimenopausal and menopausal period to limit morbidity, disability and mortality risks.