Changes in Oxidative Stress Markers in Pregnant Women of Advanced Maternal Age with Gestational Diabetes and Their Predictive Value for Neurodevelopmental Impact

Yabing Wang,1 Zhenling Fan,2 Jianli Ren,3 Lin Ma4 1Department of Obstetrical, Shijiazhuang Obstetrics and Gynecology Hospital, Shijiazhuang, Hebei Province, People’s Republic of China; 2Department of Hemodialysis, Handan Mingren Hospital, Handan, Hebei Province, People’s Republic of China; 3Department of Supplies, Peking University Third Hospital Chongli, Beijing, People’s Republic of China; 4Department of Gynecology and Obstetrics, Zhengdingxian People’s Hospital, Shijiazhuang, Hebei Province, People’s Republic of ChinaCorrespondence: Yabing Wang, Email [email protected]: To explore the relationship between changes in oxidative stress markers in pregnant women of advanced maternal age with gestational diabetes mellitus (GDM) and adverse pregnancy outcomes and neonatal neurodevelopment, as well as their predictive value.Methods: Two hundred pregnant women of advanced maternal age were selected and divided into Group A (normal blood sugar) and Group B (GDM) based on the 75 g (Oral Glucose Tolerance Test) OGTT results. Oxidative stress markers were measured, and pregnancy outcomes and neonatal Neonatal Behavioral Assessment Scale (NABA) scores were recorded.Results: Malondialdehyde (MDA) levels in Group B were higher than those in Group A, while Glutathione (GSH) and Superoxide Dismutase (SOD) levels were lower. Group B had higher rates of adverse pregnancy outcomes and neurological abnormalities than Group A. The Area Under the Curve (AUC) values for serum MDA, GSH, and SOD levels combined prediction were higher than those for individual predictions (P< 0.05).Conclusion: Oxidative stress markers in pregnant women of advanced maternal age with GDM are associated with adverse pregnancy outcomes and neonatal abnormalities, and combined prediction has good predictive efficiency (AUC> 0.7).Keywords: pregnant women of advanced maternal age with GDM, oxidative stress markers, pregnancy outcomes, neurodevelopment, correlation, predictive value