Association Between Poor Lifestyle Habits and Cutaneous Melanoma Risk: A Mendelian Randomization Study

Xiaohui Liu,1,* Wenkang Luan,2,* Shujun Fan,2 Tengfei Liu1 1Department of Burn and Plastic Surgery, Shengli Oilfield Central Hospital, Dongying, Shandong, People’s Republic of China; 2Department of Auricular Reconstruction, Plastic Surgery Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, People’s Republic of China*These authors contributed equally to this workCorrespondence: Tengfei Liu, Department of Burn and Plastic Surgery, Shengli Oilfield Central Hospital, 31 Jinan Road, Dongying, Shandong, People’s Republic of China, Email [email protected]: There is still no consensus on the risk factors of cutaneous melanoma, and the causal relationship between poor lifestyle habits (including undersleeping, smoking, alcohol consumption and sedentary behaviour) and cutaneous melanoma remains uncertain.Methods: We investigated the causal effect of poor lifestyle habits on cutaneous melanoma through the Two‐sample Mendelian randomization (MR). MR analysis was performed by using the genome‐wide association studies (GWAS) statistics. Single‐nucleotide polymorphisms (SNPs) robustly associated with undersleeping, smoking, alcohol consumption and sedentary behaviour were used as instrumental variables, we performed five MR approaches, including inverse variance weighted (IVW), weighted median, simple mode, MR-Egger and weighted mode.Results: The causal relationship between undersleeping and cutaneous melanoma was discovered in IVW (OR = 1.018, 95% CI = 1.002– 1.033, P = 0.025). However, the causal association between smoking, alcohol consumption, sedentary behaviour and cutaneous melanoma have not been found in all MR approaches.Conclusion: The MR analysis indicated that undersleeping is causally associated with the risk of cutaneous melanoma.Keywords: cutaneous melanoma, undersleeping, Mendelian randomization, poor lifestyle habits