Association Between SARS-CoV-2 Infection and Acute Ischemic Colitis

Yanping Wu,1 Yueqin Zheng,1 Sumei Sha,1 Yu Wang,2 Junyan Wang,3 Wei Zhang,4 Yixuan Lu,1 Yan Cheng,1 Jie Wu,5 Bin Qin,1 Yuan Gao6 1Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China; 2Department of Gastroenterology, Xi’an Central Hospital, College of Medicine, Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China; 3Department of Gastroenterology, the Second Affiliated Hospital of Xi ‘an Medical University, Xi’an, Shaanxi Province, People’s Republic of China; 4Department of General Internal Medicine, Staff Hospital of Changqing Oilfield, Xi’an, Shaanxi Province, People’s Republic of China; 5Department of Pathology, the Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi Province, People’s Republic of China; 6Department of Gastroenterology, Ankang Central Hospital, Ankang, Shaanxi Province, People’s Republic of ChinaCorrespondence: Bin Qin, Department of Gastroenterology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an City, Shaanxi Province, 710004, People’s Republic of China, Email [email protected] Yuan Gao, Department of Gastroenterology, Ankang Central Hospital, Ankang City, Shaanxi Province, 725000, People’s Republic of China, Email [email protected]: Ischemic colitis appears to be a rare but serious complication of COVID-19. About 33.3% hospitalized COVID-19 patients who underwent endoscopy showed features resembling ischemic colitis. The aim of this prospective study was to describe the symptoms, treatment, and outcomes of these patients, particularly their colonoscopy and histologic findings.Patients and methods: We conducted a prospective study on ischemic bowel disease associated with COVID-19 across four centers from December 2022 to January 2023. All cases were identified through a comprehensive search of electronic medical records for procedure-related data. The initial diagnosis of ischemic bowel disease was confirmed using colonoscopy and biopsy findings. After the patients were discharged, a 12-month follow-up was conducted through regular phone interviews to assess their clinical outcomes.Results: Overall, the study included 3 male patients and 9 female patients (age range, 33– 76 years). Abdominal pain and hematochezia always occurred within 2 weeks after COVID-19 infection (average 5.5 days). Gastrointestinal manifestations did not parallel the severity of COVID-19 infection. The descending colon was the most susceptible segment, which was involved in 10 patients (83.33%). Colonoscopy revealed diffuse redness, edema, bleeding, erosion, and ulceration of the intestinal mucosa, similar to the findings of ischemic colitis, and biopsy revealed crypt atrophy, reduction, and interstitial bleeding. All patients were self-limited without converting to chronic changes in the next 12 months.Conclusion: SARS-CoV-2 infection may induce transient acute colon ischemia within 2 weeks, accompanied by severe clinical symptoms such as acute abdominal pain and hematochezia, which are self-limiting and do not lead to chronic symptoms.Keywords: SARS-CoV-2, lower gastrointestinal bleeding, ischemic colitis, colonoscopy