Akromegali hastalarında yükselmiş monosit ve yüksek yoğunluklu lipoprotein kolesterol oranının endotel disfonksiyonu ve kardiyovasküler risk üzerindeki rolü

Aims: This study aimed to investigate the role of the monocyte-to-high-density lipoprotein ratio (MHR) as an indicator of endothelial dysfunction and cardiovascular risk in patients with acromegaly.Methods: The study group consisted of 125 patients diagnosed with acromegaly, while the control group included 123 healthy individuals who visited the endocrine clinic due to pituitary incidentaloma but had no acromegaly diagnosis. Medical and laboratory records of all participants were reviewed retrospectively.Results: The average MHR in patients with acromegaly was found to be statistically significantly higher than that in the healthy control group. In the acromegaly group, systolic blood pressure, glucose, HbA1c, lipids (total cholesterol, LDL, triglycerides), sedimentation rate, CRP, and neutrophils were significantly higher to the control group. The optimal MHR cutoff for acromegaly was 12.01, with 85.1% sensitivity, 85% specificity, and an AUC of 0.64.Conclusion: MHR, a potential biomarker considered an indicator of inflammation, was significantly higher in patients with acromegaly compared to the healthy control group. This finding suggests that MHR may serve as a useful marker for assessing cardiovascular risk and endothelial dysfunction in patients with acromegaly.