Advances in diagnosis, prognosis and reconstructive procedures in orthopaedic oncology

This thesis addresses advancements and ongoing challenges in the broad array of orthopaedic oncology. It reviews progress in diagnostic and prognostic tools, including the evaluation of the eNose for chondrosarcoma and the use of relative wash-in rate as a radiomics-based prognostic marker for early prediction of prognosis in osteosarcoma patients. These tools hold significant potential for personalized treatment and the development of new therapies. However, refinement and external validation is warranted<br>before these tools can be clinically adopted. The second part of this thesis underlines the crucial role of international registries in evaluating treatments for orphan diseases, with a particular focus on endoprosthetic reconstructions. It presents clinical outcomes of various MUTARS endoprostheses through<br>the first international multicenter initiative, the MUTARS Orthopaedic Registry Europe (MORE). Expanding this registry will facilitate more detailed analyses of specific complication and less common reconstructions, such as growing prostheses, intercalary reconstructions, or custom-made implants. The successful implementation of MORE represents a significant advance in orthopaedic oncology, providing a valuable platform for other centers to contribute to and utilize registry data for ongoing research. By collaborating with global experts, we can focus on addressing critical issues and advancing research that aims to improve clinical outcomes and overall patient care.<br>