Вплив перебігу COVID-19 на перинатальні ускладнення

The studies of the impact of the new global disease – coronavirus disease – on the organism of pregnant women, newborns, infants and children continue, and the pathogenetic mechanisms of such impact remain not fully defined.The objective: to determine the impact of COVID-19 on perinatal complications.Materials and methods. 200 women hospitalized with COVID-19 during pregnancy were examined. Pregnant women were divided into two groups: Group 1 consisted of 50 women with perinatal complications (fetal distress, fetal growth retardation, preterm birth, severe neonatal asphyxia, perinatal death), Group 2 consisted of 150 patients with a physiological course of pregnancy.Results. It was found that in pregnant women with perinatal complications, the course of COVID-19 disease has certain differences compared to patients without perinatal disorders. A significantly higher rate of women with perinatal complications who became ill with COVID-19 in the III trimester of pregnancy was found (80.0 vs 54.0%, respectively, p < 0.05). In Group 1, there were almost 2 times more women who felt sick for 5 to 10 days at the time of hospitalization (34.0 vs 18.0% in Group 2, p < 0.05) and 2.5 times more women who were sick for more than 10 days (18.0 vs 7.3%, respectively, p < 0.05). It is noteworthy that the frequency of severe COVID-19 in pregnant women with perinatal disorders is almost 3 times higher than in women with a physio-logical course of pregnancy (66.0 vs 22.7%, p < 0.05). In Group 1, an increased frequency of all components of the severity of the disease was found by 2 times or more compared to Group 2, in particular pneumonia (70.0 vs 24.7%, p < 0.05), hyperthermia (58.0 vs 21.3%, p < 0.05), which lasted more than 5 days (26.0 vs 6.7%), SpO2 less than 93% (78.0 vs 23.3%, p < 0.05).Conclusions. Manifestations of severe COVID-19 in pregnant women, such as pneumonia, hyperthermia, low saturation, are risk factors for perinatal complications in such women, which requires the development and implementation of a system for predicting and preventing perinatal disorders.