Системне запалення як чинник морфогенезу уражень артерій

The article analyzes modern ideas about the role of inflammation at the initial stage of arterial involvement. Research in the recent years has led to the formation of the new understanding of atherosclerosis – as a chronic low-intensity inflammatory process in the vessel wall. It means that blood cells and endothelium release proinflammatory cytokines, the cascade of various biologically active molecules, that act as activators and inhibitors of inflammation. The final stage of this process - atherothrombosis, which is the direct cause of such vascular accidents as myocardial infarction and stroke, also occurs with the active participation of these factors. The most studied today is the role of C-reactive protein, the role of the other factors and inflammation markers is still unknown. If inflammation is one of key factors of atherogenesis and pathogenesis of coronary heart disease, the consideration of this factor is essential both for treatment correction and for reconsideration of the disease prognosis. The correction effect on inflammation is a necessary component of pathogenetically substantiated treatment of patients with coronary heart disease.