TROPONIN I LEVELS IN BLOOD AS A BIOMARKER FOR ASPHYXIATION PROCESS IN DEATH DUE TO MECHANICAL ASPHYXIA

During mechanical asphyxia, a number of morphological signs appear in the body, which are called general asphyxiation. They do not prove the presence of an asphyxiated state during death by mechanical asphyxia, as they occur with any rapid death. The heart, as the most metabolically active organ, responds to oxygen deficiency with the appearance of metabolic disorders and death of cardiomyocytes, which leads to the release of free troponin complex into the bloodstream, which is actively used in the diagnosis of myocardial diseases. The aim of the study is to determine the quantitative content of Troponin I, as a diagnostic marker of the asphyxiation process, in the blood of those who died from mechanical asphyxia. Materials and methods. The study used blood serum from those who died from mechanical asphyxia and sudden death from cardiac pathology. The content of Troponin I was detected by a “sandwich” variant of solid-phase enzyme immunoassay using a set of reagents from the company “Hema” (Ukraine). The resulting digital material was processed using a statistical package. Results. Our study showed that in cases of death from mechanical asphyxia, there is a significant increase in the content of Troponin I in the blood, the maximum average value of which is higher compared to cases of death from cardiac pathology. Conclusions. The level of Troponin I in the blood can be a diagnostic marker of asphyxiation in cases of death from mechanical asphyxia, in particular, from hanging and obstructive asphyxia.