Trauma and thrombosis in the DOAC era: promise and peril of direct oral anticoagulant use in injured patients

This dissertation focuses on three main research questions: what role do direct oral anticoagulants have in the prevention of venous thromboembolism in trauma patients? How do treatment and outcome differ between trauma patients who use DOACs chronically versus those who use vitamin K antagonists? And third, what are the hemostatic effectiveness and safety of two reversal agents used to treat DOAC - specifically Factor Xa inhibitor - associated bleeding in trauma patients?<br>