Peculiarities of the psychological state of pregnant women with HCV infection

Aim - to establish the peculiarities of the psychological status of pregnant women with HCV infection in order to prevent their disorders in the pre-pregnancy period. Materials and methods. A prospective assessment of the psychological status of 100 patients, divided into two groups, was carried out: the Main group (МG) - 60 pregnant women with chronic hepatitis C (HCV infection) in the reactivation phase (with a positive result by the enzyme immunoassay method for anti-HCV), the control group (СG) - 40 healthy pregnant women. Pregnant women were offered to work with questionnaires using the following methods: assessment of parameters of the level of anxiety (HARS) according to Hamilton, assessment of well-being, activity and mood, questionnaire of quality of life SF-36. Statistical processing of research results was carried out using standard programs "Microsoft Excel 5.0" and "Statistica 8.0". Differences at p<0.05 are considered statistically significant. Results. In the I trimester, pregnant women with HCV infection had an increased level of anxiety (Me (Q1-Q2)) as somatic (4.0 (0.5-6.0) and 0.0 (0.0-1.5), respectively CG; mental (4.0(2.5-6.0) and 1.0 (0.0-2.0), respectively; 0 (0.0-2.0), respectively. In the II trimester, there was a significant difference in total anxiety (10.0 (6.0-15.0) and 6.0 (2.0-11.0), respectively, in pregnant women with HCV infection when compared with healthy pregnant women in all parameters, especially due to the mental component (4.0 (2.0-7.0) and 1.0 (0.0-3.0), respectively. In the III trimester, a high level of differences was found only in the mental component, which on the median was 2 times higher than the level of mental anxiety in pregnant MG (4.0 (1.0-6.0) and 2.0 (0.0-3, 0), respectively; there was a decrease in the total quality of life (46.0 (42.0-51.0) and 52.0 (46.0-56.5), respectively, in all parameters, except for the family assessment (8.0 (6.0-8.0) and 8.0 (7.0-8.0)). Conclusions. HCV infection during pregnancy is a risk factor for the development of anxiety and is characterized by an increase in the level of anxiety and a decrease in the quality of life throughout pregnancy, especially due to the mental component, which indicates the need to study the relationship between these factors and the frequency of complications during pregnancy, childbirth and postpartum period, as well as the condition of newborns in these women and possible ways of correcting the psychological status to reduce the frequency of obstetric and perinatal complications in the pre-gravid period. The study was carried out in accordance with the principles of the Declaration of Helsinki. The study protocol was adopted by the Local Moral Committee of the institution indicated in the work. Informed consent was obtained from the women for the study. No conflict of interests was declared by the author.