Innovations in musculoskeletal tumor surgery: from margin optimization to stable fixation

Part I investigates how fluorescence-guided surgery can improve surgical margins in sarcomas. A radical operation, in which the tumor is completely removed, offers the best chance of success. Unfortunately, many soft tissue sarcomas grow infiltratively, with extensions that are difficult to detect. This poses a challenge during surgery, as the surgeon must remove the tumor with a margin of healthy tissue to minimize the chance of local recurrence. In Part I, tumor-specific biomarkers for infiltratively growing sarcomas, such as Myxofibrosarcoma and Ewing Sarcoma, are identified. Part II focuses on innovative carbon-fiber implants as an alternative to metal implants. These implants offer several material-specific advantages over metal, such as fewer artifacts on CT images, which can improve follow-up and radiotherapy planning. Carbon-fiber implants appear to be a safe and effective alternative for reconstructions following bone tumor resections, though randomized studies are recommended for further validation. The research highlights the promise of targeted FGS and CF implants, recommending future trials to confirm clinical benefits. <table><tbody></tbody></table>