FAT1 alterations contribute to chromosomal instability in cancer cells

Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.

Publication Details

Journal
UCL Discovery (University College London)
Published
2025-01-01
Primary Topic
Microtubule and mitosis dynamics
Type
article
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article

FAT1 alterations contribute to chromosomal instability in cancer cells

UCL Discovery (University College London)
Microtubule and mitosis dynamics
article

FAT1 alterations contribute to chromosomal instability in cancer cells

article en

Abstract

Combining genomics data from the TRACERx non-small-cell lung cancer (NSCLC) cohort and experimental data, we report that alterations in FAT1 are selected early during lung cancer evolution and cause chromosomal instability and whole-genome doubling.

UCL Discovery (University College London)
Openalex Percentile: Top 45%
Microtubule and mitosis dynamics
OpenAlex
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FAT1 alterations contribute to chromosomal instability in cancer cells · UCL Discovery (University College London) (2025) | TGRS Research Map | TGRS