Expert Consensus on Transcranial Direct Current Stimulation Combined with Cognitive Training in the Treatment of Early Alzheimer's Disease

Transcranial direct current stimulation (tDCS) combined with cognitive training (CT) is a therapeutic method of combining neuromodulation technology with cognitive rehabilitation training. Its core is to enhance the cognitive function of the brain with CT intervention, while using tDCS to regulate the excitability of the cerebral cortex to promote neural plasticity and functional recovery. This consensus summarizes the clinical applications of tDCS combined with CT, including contraindications, assessment methods (such as neuropsychological tests, functional magnetic resonance imaging, electroencephalography, multimodality magnetic resonance imaging analysis, and near-infrared functional brain imaging), and effects on sensory perception, attention, working memory, decision-making, and other cognitive abilities. The recommended targets for tDCS treatment of AD include left dorsolateral prefrontal cortex (DLPFC), temporal and parietal cortex, frontotemporal cortex and angular gyrus; electrical stimulation and synchronous stimulation of CCT; CCT training content：mainly including attention, memory, perception and logical reasoning; The current intensity was 1~2 mA, the stimulation time was 20 min/time, 5 times/week, and lasted for 3 weeks as a course of treatment. Treatment should be carried out in strict accordance with equipment requirements, operation specifications, safety and precautions. Future studies should further optimize the treatment parameters and explore its application potential in patients with different cognitive disorders. Therefore, tDCS combined with CT is a rehabilitation treatment method with scientific basis, high safety and remarkable effect, which is of great significance to improve the quality of life of patients.