Enhancement of OECT-Based Biosensors Through Synthetic Manipulation of Semiconducting Polymers

Organic electrochemical transistors (OECTs) represent a promising class of organic thin-film transistors with significant potential as biosensors. The biocompatibility, low voltage operation, flexibility, and high sensitivity to a wide range of bioanalytes make OECTs particularly attractive for applications in biosensing technology. These advantages position OECTs at the forefront of the next generation of biosensing devices. In this presentation, we will discuss our innovative designs for semiconducting copolymers, which are based on ethylenedioxythiophene (EDOT) and isoindigo units. These copolymers are instrumental in the development of more efficient and sustainable OECT-based sensors. Our research approach involves a comprehensive examination of the electronic properties of these novel devices and the optimization of various materials. Our goal is to achieve superior OECT performance while minimizing environmental impact. This presentation will discuss the synthetic pathways we will work to develop to access these new polymers as well as showcase the characterization of biosensors constructed from these materials. This will include highlighting the devices' sensitivity, response times, and stability, illustrating their potential in practical applications. The outcomes of this research will offer new avenues in biosensing technology, as well as more efficient and sustainable OECT-based sensors with the potential to greatly enhance healthcare and diagnostic capabilities.