The Diagnostic Value of Serum MCP-1 Combined with OPN Detection for Early Renal Injury in Gout Patients

Haiying Chang,1 Jing Lv,1 Yinglin Zheng,2 Dongsheng Li,1 Yi Li2 1Rheumatology Department, Ganzhou People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of China; 2Endocrinology Department, Ganzhou People’s Hospital, Ganzhou, Jiangxi, 341000, People’s Republic of ChinaCorrespondence: Yi Li, Department of Endocrinology, Ganzhou People’s Hospital, No. 17 hongqi Avenue, Zhanggong District, Ganzhou, Jiangxi, 341000, People’s Republic of China, Tel +8618270976372, Email [email protected]: To explore the changes in serum Monocyte chemoattractant protein-1 (MCP-1) and Osteopontin (OPN) in gout patients and their diagnostic value for early renal injury.Methods: In this research, 174 gout patients (January 2022–October 2024) were divided into the early renal injury group (50 cases) and non-early renal injury group (124 cases). Additionally, 169 healthy individuals were included as controls. Clinical indicators such as serum creatinine, cystatin C (CysC), and GFR were recorded. MCP-1 and OPN levels were measured using ELISA. Pearson’s correlation was used to analyze relationships; Logit regression was applied to identify influencing factors, and ROC curves assessed diagnostic value, with AUC comparisons via Z-test.Results: Serum MCP-1 and OPN levels were significantly higher in the gout group compared to controls (P< 0.05) and further elevated in the early renal injury group (P< 0.05). MCP-1 and OPN correlated positively with creatinine and CysC and negatively with GFR (P< 0.05). Logit regression identified MCP-1 (OR: 2.765, 95% CI: 1.308– 5.846) and OPN (OR: 3.019, 95% CI: 1.468– 6.210) as independent risk factors (P< 0.05). The AUC for diagnosing early renal injury was 0.775 (MCP-1), 0.827 (OPN), and 0.938 (combined), with the combination significantly outperforming either marker alone (Z=3.075, 2.273, P< 0.05).Conclusion: The combination of serum MCP-1 and OPN in gout patients has a higher diagnostic value for early renal injury, it is obviously higher than the individual diagnosis of each indicator, and demonstrates significant clinical implications.Keywords: gout, early renal injury, monocyte chemoattractant protein-1, osteopontin, diagnosis